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Clindamycin/benzoyl peroxide - Wikipedia.
Common side effects include peeling, itching, and dryness of the skin where the gel was applied. The gel is used on the skin to treat light to medium acne vulgaris in people 12 years and older. While oral clindamycin passes into breast milk, no such data are available for clindamyin in gel form. Limited data regarding topical clindamycin and benzoyl peroxide have shown no safety problems.
The gel is not recommended for those who are allergic to clindamycin, benzoyl peroxide, any components of the formulation, or lincomycin. Common side effects are peeling, itching, redness, dryness, burning, and dermatitis. Benzoyl peroxide bleaches hair, clothes, towels, bedclothing, and the like. Prolonged exposure to natural or artificial sun light UV rays is not recommended because the gel may cause photosensitivity.
Clinical studies have shown systemic absorption of clindamycin through topical application, in some cases leading to diarrhea, bloody diarrhea, and colitis. Reports of anaphylaxis were also seen. No formal interaction studies have been done. Topical erythromycin may antagonise the effect of clindamycin, although this has only be demonstrated in in vitro studies. Topical tretinoin and other retinoids may be inactivated by benzoyl peroxide or increase its irritant effect.
Clindamycin phosphate is a water-soluble ester of the semi-synthetic antibiotic clindamycin, which is synthesized from lincomycin. Like the macrolide antibiotics, it acts as a bacteriostatic agent by interfering with the 50S subunit of the ribosome of Cutibacterium acnes , inhibiting bacterial protein synthesis and preventing bacteria from replicating.
Benzoyl peroxide also kills C. Also, it dries out the area by reducing sebum production, prevents clogged pores , and is a keratolytic agent.
Both ingredients have been shown to reduce the number of acne lesions with statistical significance. Clindamycin phosphate is an inactive prodrug.
It is quickly activated to clindamycin by hydrolysis. After four weeks of application during a study, 0. Benzoyl peroxide is only absorbed through the skin after reduction to benzoic acid , which is subsequently metabolized to hippuric acid and eliminated via the kidneys. The combination is sold under various brand names including Acanya, [4] Benzaclin, [3] Duac, [6] and Onexton.
The court concluded that Taro was guilty of attempting to submit an ANDA patent request before the Onexton patent expired. From Wikipedia, the free encyclopedia. Type of medication. US DailyMed : Clindamycin phosphate and benzoyl peroxide.
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Austria-Codex in German. The Medical Letter on Drugs and Therapeutics. August PMID Journal of the American Academy of Dermatology. Retrieved 19 November ISBN Merck Manual of Diagnosis and Therapy. November Archived from the original on 2 December Retrieved 1 December S2CID American Journal of Clinical Dermatology. Taro Pharmaceuticals U. Food and Drug Administration. Archived from the original on 16 April Retrieved 15 April Archived from the original on 26 October Acne -treating agents D Azelaic acid Benzoyl peroxide 8-Hydroxyquinoline Blue light therapy Tea tree oil.
Glycolic acid Salicylic acid Sulfur Benzoyl peroxide. Niacinamide Ibuprofen Aspirin Red light therapy. Thomas Beecham Silas M. Burroughs Mahlon Kline John K. Canada v. GlaxoSmithKline Inc. Christopher v.
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