Can you take methylprednisolone and azithromycin together.Evidence-Based Complementary and Alternative Medicine
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Can You Take Steroids and Antibiotics Together?
To explore and analyze the efficacy of methylprednisolone combined with azithromycin in the treatment of refractory Mycoplasma pneumoniae pneumonia RMPP and its effect on the changes of T lymphocyte subsets.
Outcome measures included clinical efficacy, symptoms mitigation, changes in inflammatory factors, T lymphocyte subsets, and adverse reactions. Compared with the control group, the total clinical effective rate of the observation group was higher. The disappearance time of cough, wheezing, pulmonary rales, and X-ray lung shadows in the observation group was significantly shorter than that in the control group after treatment.
There was no significant difference in adverse reactions between the two groups during treatment. Methylprednisolone plus azithromycin might serve as an alternative in the treatment of RMPP. It facilitates the mitigation of clinical symptoms and signs and regulates the level of inflammatory factors and cellular immune dysfunction, with good effectiveness and a high safety profile.
Previously, the disease was believed to resolve spontaneously and was considered self-limiting. However, the increasing high incidence of refractory Mycoplasma pneumoniae pneumonia RMPP imposes substantial challenges on clinical treatment. The disease progresses rapidly and may lead to the involvement of the lungs. Complications such as respiratory distress syndrome and respiratory failure may occur in severe cases [ 2 ].
Methylprednisolone can be used in various acute infections, immune system disorders, or allergic diseases. It has anti-inflammatory and antiallergic effects, inhibits the proliferation of connective tissue, reduces the permeability of capillary walls and cell membranes, alleviates inflammatory reactions, restrains the formation and release of histamine and toxic substances, promotes the decomposition of proteins into sugar, and diminishes the utilization of sugars.
As a reliable drug for the treatment of Mycoplasma pneumoniae in the current clinical work, azithromycin belongs to the second-generation macrolide antibiotics, but its efficacy in the treatment of RMPP is modest [ 3 ]. Therefore, glucocorticoid treatment is suggested in addition to antibiotics, which exerts a strong inhibitory effect on the inflammatory response and regulating the immune function of the body [ 4 ].
Accordingly, methylprednisolone combined with azithromycin was used in the present study for the treatment of RMPP to study its efficacy. The control group included 35 males and 25 females, aged 3—8 years, with a mean age of 5. There were 38 males and 22 females in the observation group, aged 2—7 years, with an average of 5. The baseline data in the two groups were comparable.
Inclusion criteria: all patients with diagnosis conforming to the relevant criteria for RMPP in Practical Pediatrics [ 5 ], with an ineffective treatment outcome of macrolide antibiotics for 1 consecutive week, with different degrees of increased lung texture and patchy and slightly high-density shadows with blurred boundaries on X-ray, aged less than 14 years, and the family members of the children signed the informed consent form.
Exclusion criteria: patients with congenital heart diseases, bronchopulmonary diseases, and innate immune diseases; with severe liver and kidney dysfunction; with contraindications to glucocorticoids such as tuberculosis at different sites and peptic ulcers; with allergic reactions to the medication used in the present study; those who cannot cooperate with this experiment; and those who lack clinical data. Both groups were given conventional treatment such as oxygen inhalation, phlegm removal, cough relieving, and body temperature control.
On the basis of the control group,the observation group was additionally given methylprednisolone Pfizer Inc. The clinical efficacy, disappearance time of main symptoms and signs, changes in inflammatory factors, and T lymphocyte subsets before and after treatment were compared between the two groups, and adverse reactions during treatment were recorded.
SPSS Statistical significance was assumed as. Compared with the control group, the total clinical effective rate of the observation group was higher, and the difference was statistically significant , as given in Table 1. The disappearance time of cough, wheezing, pulmonary rales, and X-ray lung shadows in the observation group was significantly shorter than that in the control group after treatment , as given in Table 2. There was no significant difference in adverse reactions between the two groups during treatment , as given in Table 5.
Therefore, effective treatment is crucial for disease control. Currently, the second-generation macrolide antibiotic azithromycin is the mainstay for mycoplasma pneumonia, which can effectively control the progression of the disease and inhibit infection [ 8 ]. Studies have shown a significant increase in the levels of inflammatory factors in children with Mycoplasma pneumoniae pneumonia due to pulmonary infection.
Mycoplasma can stimulate the body to cause abnormal immune function and secrete a large number of cytokines through the activation of lymphocytes, among which the release of a series of proinflammatory factors such as IL-6 and IL-8 can further aggravate the inflammatory response [ 10 ]. IL-6 is an important cytokine in the inflammatory response, and its overexpression can lead to multiorgan and systemic damage. IL-8 causes inflammatory cells to accumulate and release large amounts of active substances through chemotaxis of neutrophils and T lymphocytes.
Its overexpression is associated with tissue damage and reflects the degree of infection and regression of pediatric mycoplasma pneumonia. However, it has been found that macrolide drugs are predisposed to drug resistance in the long-term treatment of mycoplasma pneumonia, and the effect of single drug use is mediocre and even increase in the incidence of macrolide drug-resistant pneumonia [ 9 ].
In addition, the addition of methylprednisolone on the basis of azithromycin can also significantly enhance the antiinfective effect through the synergistic effect of the two drugs [ 12 ]. The results of the present study showed that methylprednisolone combined with azithromycin in the treatment of RMPP leads to a remarkable clinical efficacy and faster mitigation of symptoms, suggesting a promising efficacy of methylprednisolone combined with azithromycin in the treatment of RMPP, which is highly consistent with previous research [ 13 ].
Moreover, the addition of methylprednisolone herein resulted in a significantly lower inflammatory factors level in the children. To the best of our knowledge, the abnormal T lymphocyte subsets are associated with immune disorders, and the monitoring of the number of T lymphocyte subsets is of great significance in the diagnosis and prognosis of patients [ 14 , 15 ].
Here, methylprednisolone combined with azithromycin resulted in better outcomes in terms of inflammatory responses and T lymphocyte subsets versus conventional treatment, confirming that the addition of methylprednisolone benefits the cellular immune dysfunction and immune response of the body, thereby promoting further alleviation of symptoms and signs.
Furthermore, the absence of adverse reactions during the treatment with methylprednisolone suggested a high safety profile of methylprednisolone. Therefore, treatment should be based on clearing the lung, relieving cough, calming asthma, and resolving phlegm.
The medicinal herbs of Wuhu decoction contain ephedra, bitter almonds, gypsum, and licorice. Ephedra is the monarch drug, which can relieve the symptoms of sweating, promote the lung, and relieve asthma; gypsum is the minister drug, which is pungent and cold in nature, can clear heat and remove annoyance, and relieve asthma and cough; bitter almond is the adjuvant drug, which can promote the lung and relieve cough and phlegm, and licorice is the ambassador drug, which can moisten the lung, relieve cough, dispel phlegm, relieve spasm, and harmonize the drugs.
The combination of these herbs can promote lung circulation, clear heat, dissolve phlegm, stop coughing, and relieve asthma. The limitations of this study are the absence of long-term follow-up and the inadequate collection of medical data of the patients after discharge. The follow-up period will be extended to obtain more reliable clinical data in future studies. The datasets used to support this study are available from the corresponding author upon request.
Yin and X. Yan, H. Sun, H. Zhao et al. Shuang, S. Ma, and H. Yu, H. Zhang, Z. Chen, W. Gu et al. Hou, S. Zhang, and W. Wu, X. Ding, D. Zhao, and Y. Zhu and J. Tan and M. On this page. Jun Lv 1 and Fei Fan 1. Academic Editor: Zhaoqi Dong. Received 02 Mar Published 26 Apr Abstract Objective. Methods Both groups were given conventional treatment such as oxygen inhalation, phlegm removal, cough relieving, and body temperature control.
Efficacy Evaluation Criteria The clinical efficacy, disappearance time of main symptoms and signs, changes in inflammatory factors, and T lymphocyte subsets before and after treatment were compared between the two groups, and adverse reactions during treatment were recorded. Results 4. Comparison of Clinical Efficacy Compared with the control group, the total clinical effective rate of the observation group was higher, and the difference was statistically significant , as given in Table 1.
Table 1. Table 2. Comparison of the disappearance time of main symptoms and signs between the two groups d. Table 3. Comparison of the levels of inflammatory factors before and after treatment in the two groups. Table 4. Comparison of T lymphocyte subsets levels before and after treatment in the two groups. Table 5. References Y. View at: Google Scholar. View at: Publisher Site Google Scholar. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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❾-50%}EFFECT OF COMBINATION OF METHYLPREDNISOLONE AND AZITHRO - Can You Take Steroids and Antibiotics at the Same Time?
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Drug information provided by: IBM Micromedex. Azithromycin is used to treat certain bacterial infections in many different parts of the body. This medicine may mask or delay the symptoms of syphilis. It is not effective against syphilis infections. Azithromycin belongs to the class of drugs known as macrolide antibiotics. It works by killing bacteria or preventing their growth.
However, this medicine will not work for colds, flu, or other virus infections. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals.
For non-prescription products, read the label or package ingredients carefully. Appropriate studies have not been performed on the relationship of age to the effects of azithromycin to treat sinusitis in children or to treat pneumonia in children younger than 6 months of age.
Safety and efficacy have not been established. Appropriate studies have not been performed on the relationship of age to the effects of azithromycin oral suspension and tablets to treat pharyngitis or tonsillitis in children younger than 2 years of age. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of azithromycin in the elderly. However, elderly patients are more likely to have heart rhythm problems eg, torsades de pointes which may require caution in patients receiving azithromycin.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below.
The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases.
If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur.
Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine.
Make sure you tell your doctor if you have any other medical problems, especially:. Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This medicine comes with a patient information leaflet.
Read and follow the instructions carefully. Ask your doctor if you have any questions. Measure your dose correctly with a marked measuring spoon, oral syringe, or medicine cup.
The average household teaspoon may not hold the right amount of liquid. You or your child must take this medicine within 12 hours after it has been mixed with water. If your child does not use all of the medicine in the bottle, throw it away after you give the dose. Keep using this medicine for the full treatment time, even if you or your child feel better after the first few doses.
Your infection may not clear up if you stop using the medicine too soon. These medicines may keep azithromycin from working properly. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine.
Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you miss a dose of this medicine, take it as soon as possible.
However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. After water has been added to the powder, use the dose within 12 hours and throw away any unused liquid after your dose. Do not freeze the bottle. Do not keep the oral liquid for more than 10 days.
Throw away any unused liquid after all doses are completed. It is very important that your doctor check the progress of you or your child at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects. If you or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.
This medicine may cause serious allergic reactions, including anaphylaxis and angioedema, which can be life-threatening and require immediate medical attention. Call your doctor right away if you or your child have a rash, itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you take this medicine.
Serious skin reactions, including Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms DRESS can occur with this medicine.
Check with your doctor right away if you or your child have black, tarry stools, blistering, peeling, or loosening of the skin, chest pain, chills, cough, diarrhea, itching, joint or muscle pain, painful or difficult urination, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, swollen glands, unusual bleeding or bruising or unusual tiredness or weakness while you are using this medicine.
Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem. Call your child's doctor right away if your child feels irritable or vomits after feeding. These may be symptoms of a condition called infantile hypertrophic pyloric stenosis. Azithromycin may cause diarrhea, and in some cases it can be severe.
It may occur 2 months or more after you stop using this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer.
If you or your child have any questions about this or if mild diarrhea continues or gets worse, check with your doctor. This medicine can cause changes in heart rhythms, including QT prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients. Contact your doctor right away if you or your child have any symptoms of heart rhythm problems, including fast, pounding, or irregular heartbeats.
This medicine may increase the risk of serious heart or blood vessel problems. Call your doctor right away if you have blurred vision, chest pain, confusion, lightheadedness, dizziness, fainting, fast or irregular heartbeat, trouble breathing, or unusual tiredness or weakness.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription over-the-counter [OTC] medicines and herbal or vitamin supplements.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.
Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.
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No interactions were found between azithromycin and prednisone. However, this does not necessarily mean no interactions exist. Conclusion. Methylprednisolone plus azithromycin might serve as an alternative in the treatment of RMPP. It facilitates the mitigation of clinical symptoms and. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines. Methylprednisolone plus azithromycin might serve as an alternative in the treatment of RMPP. It facilitates the mitigation of clinical. between Azithromycin Dose Pack and MethylPREDNISolone Dose Pack. All rights reserved. Steroids, Antibiotics, and Meningitis: Plos One. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The combo can result in nausea, vomiting, rapid heart rate, and headaches. The limitations of this study are the absence of long-term follow-up and the inadequate collection of medical data of the patients after discharge.In low doses, steroids can help ease joint pain from your RA. When taking a steroid, though, you need to be cautious about combining it with other medications, like antibiotics.
Many people wonder: Is it okay to take antibiotics with steroids? Can the steroid enhance the antibiotic? We asked top medical experts to set the record straight about taking steroids and antibiotics together. Steroids also known as corticosteroids are medications that decrease inflammation in the body.
Doctors often prescribe them to treat joint inflammation and swelling, like that which results from RA. Steroids are also used to treat allergic reactions, help with breathing conditions such as asthma, and calm an overactive immune system in people with autoimmune diseases such as lupus and RA, where the immune system mistakenly attacks healthy tissue.
Some common types of oral corticosteroids are prednisone, methylprednisolone, dexamethasone, and cortisone. Antibiotics work a bit differently. So, for example, you might take an antibiotic to fight an infection such as strep throat, an ear infection, or a sinus infection.
There are many different classes and types of antibiotics; talk with your doctor about the right one for you. The answer to this question depends on the specific steroid, antibiotic, and the infection—but yes, in some cases, your physician may prescribe both drugs at the same time. The antibiotic targets bacteria and the steroid controls inflammation and resulting pain.
For example, the steroid dexamethasone has proven effective in adults with bacterial meningitis, according to a study in The New England Journal of Medicine. The two are also often prescribed together for certain infections. Still, there are some potential interactions you should be aware of when taking both oral steroids and antibiotics.
Here are common ones to be mindful of. Always talk with your provider if you are unsure about drug interactions or have follow-up questions.
There is a potential interaction between dexamethasone, a type of steroid, and certain antibiotics. The antibiotic erythromycin can raise the amount of dexamethasone in your system, increasing your risk of side effects. All corticosteroids, including prednisone, carry the risk of interacting with quinolone antibiotics levofloxacin, ciprofloxacin and causing a tendon tissue that connects muscle to bone to rupture.
Mixing prednisone and penicillin antibiotics such as amoxicillin is considered safe, says Madison. Alcohol can increase your risk of side effects while on certain medications. You should avoid alcohol while taking certain antibiotics such as Flagyl metronidazole , Tindamax tinidazole , and Bactrim sulfamethoxazole.
The combo can result in nausea, vomiting, rapid heart rate, and headaches. There are no known interactions between alcohol and steroids such as prednisone but drinking large amounts of alcohol may increase your side effects, including an upset stomach. To be safe, avoid drinking while taking oral steroids or at the very least, limit your intake. Every drug carries a risk of side effects, and steroids and antibiotics are no different.
But in the case of these two drugs, the gastrointestinal side effects can be worse when combined. For example, common side effects of antibiotics are nausea, diarrhea, and upset stomach. Corticosteroids can also cause an upset stomach and cramping , as they irritate the stomach lining.
So in short, combining antibiotics and steroids may increase the risk of stomach issues. This is meant to speed up your healing. Some research has suggested that the two medications work better together than either one alone in treating certain infections.
For example, a recent review found that corticosteroids and antibiotics were more effective together in treating bacterial meningitis. Research on mice has also shown that taking steroids and antibiotics together improved recovery time for those with pneumonia.
Steroids, Antibiotics, and Meningitis: Plos One. Prednisone Uses and Interactions: MedlinePlus. Alcohol and Antibiotics: Mayo Clinic. Krista Bennett DeMaio has well over a decade of editorial experience. The former magazine-editor-turned-freelance writer regularly covers skincare, health, beauty, and lifestyle topics. Her work has appeared in national more. What can we help you find? Rheumatoid Arthritis. Research suggests the two might work better together to fight certain infections.
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