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We chose the topical treatment with 0. After 2 months there was mild decrease of the papules, growth of hairs on the armpits and moderate improvement of the itch Figure 2. Erythema and burning sensation were evidenced after 15 days of using the retinoid on the armpits and the patient was instructed to apply the medication every other night, with resolution of the side effects. Fox-Fordyce disease is a chronic disorder of the apocrine glands which affects mostly young women.
There are few reports in prepubescent patients, although, according to more recent literature, the disease is little diagnosed in this age group. The typical lesions are firm, skin colored or yellowish papules, restricted to areas where there are apocrine glands like armpits, pubic area, areola and, more rarely, periumbilical and pre-sternal areas.
The affected areas show reduction of sweating, although the disease might be associated with hyperidrosis, as well as rarefaction or even absence of hairs. Itch is an invariable symptom, which can be aggravated by emotional factors, heat, and during the menstrual period. The etiology remains unknown. It is postulated that a hormonal disturbance is involved, although no laboratorial abnormality has been detected.
So far no genetic factor has been blamed either, despite the existence of familial cases. Besides, her laboratorial exams were normal and there were no clinical signs of hormonal alterations.
The physiopathology consists on the obstruction of the apocrine gland duct by a keratin plug in its insertion on the hair follicle wall, which causes secretion retention with consequent rupture of the glandular structure and secondary inflammation of the dermis. The extravasation of the glandular content can be the cause of the itch. The histopathological exam can show spongiosis and spongiotic vesiculation of the follicular infundibulum adjacent to the exit of the apocrine gland duct.
In some cases a keratin plug can be seen above this area. An associated mild inflammatory infiltrate is described, which can be composed of chronic inflammatory cells and neutrophils. The histopathological findings of the present case were compatible with the literature, confirming the diagnosis of Fox-Fordyce Disease.
On the case reported, other hypothesis were considered, like keratosis pilaris and lichen planopilaris, which were refuted by the histopathological exam. Other differential diagnoses are amyloidosis lichenoides, lichen nitidus, eruptive syringoma, contact dermatitis, infectious folliculitis and scabies. Fox-Fordyce Disease is chronic and might have partial or complete remission after menopause, with the use of contraceptives and during pregnancy.
Various treatments were suggested, including the administration of estrogens via oral contraceptives, topical, intralesional or systemic corticosteroids, topical and oral retinoid, topical clindamicin, pimecrolimus, phototherapy and surgical treatments like electro coagulation and curettage with liposuction.
On the reported case we preferred not to use oral contraceptives due to the age of the patient. The use of topical corticosteroid was deferred as it would be applied to a fold area and thin skin, which could cause atrophy and stretch marks. Open menu Brazil. Anais Brasileiros de Dermatologia. Open menu. Abstract Resumo English Resumo Portuguese. Text EN Text English. Apocrine glands; Fox-Fordyce disease; Retinoids; Treatment outcome.
Apocrine sweat retention in man. Fox-Fordyce disease apocrine miliaria. AMA Arch Dermatol. Fox-Fordyce disease: diagnosis with transverse histologic sections. J Am Acad Dermatol. Amado , M. Coping with Acne vulgaris V. Niemeier , J. Kupfer , M. Demmelbauer-Ebner , U. Stangier , I. Effendy , U. Gieler Psychology, Medicine. Acne is prevalent but use of its treatments is infrequent among adolescents from the general population T. Nijsten , S. Rombouts , J. Lambert Medicine, Psychology.
Prevalence of facial acne in adults. Goulden , G. Stables , W. Cunliffe Medicine. Journal of the American Academy of Dermatology. Acne and diet. Wolf , H. Matz , E. Orion Medicine. Clinics in dermatology. The effect of a high-protein, low glycemic-load diet versus a conventional, high glycemic-load diet on biochemical parameters associated with acne vulgaris: a randomized, investigator-masked, controlled trial.
Robyn N Smith , N. Mann , A. Braue , H. Varigos Medicine. Related Papers. Abstract 17 Citations 22 References Related Papers.
The Fox-Fordyce disease is a rare inflammatory dermatosis that affects mainly young women and is characterized by multiple follicular papules, skin color or brownish, very itchy, localized in areas rich in apocrine glands.
Histopathology shows focal spongiosis of the upper infundibulum with fibrosis and perifollicular lymphohistiocytic infiltrate. The diagnosis is based on clinical and histopathological examination. Many treatment options have been described; however none of them is excellent. We chose the topic adapalene 0. Fox-Fordyce disease: response to adapalene 0.
Fox-Fordyce disease, also known as apocrine miliria, is a rare inflammatory dermatosis, characterized by multiple follicular papules, skin color or brownish, located in areas rich in apocrine glands, like arm pits, periareolar areas, and pubic area, accompaniedby itch. Here we describe the case of an 11 year old girl with cutaneous lesions on the armpits and pubic area for 2 years, which appeared just after menarche at 9 years of age.
At examination we observed small normochromic papules measuring up to 2 mm, predomi nantly follicular, on the armpits and pubic area, where a rarefaction of hairs was noted. Incision biopsy of the right armpit showed hypekeratosis, parakeratosis and irregular acanthosis over the area of the apocrine gland exit, as well as spongiosis along the epidermis also involving the hair follicle, which still showed neutrophils exocytosis. The dermis had a mild, superficial, perivascular and interstitial lymphocytic infiltrate.
The histopathological exam was compatible with Fox-Fordyce Disease Figure 1. No abnormalities were found at the laboratorial exams. Although the sexual hormones were not checked, the patient did not have any clinical sign of hormonal dysfunction, like menstrual irregularity, obesity, hirsutism or acne.
We chose the topical treatment with 0. After 2 months there was mild decrease of the papules, growth of hairs on the armpits and moderate improvement of the itch Figure 2. Erythema and burning sensation were evidenced after 15 days of using the retinoid on the armpits and the patient was instructed to apply the medication every other night, with resolution of the side effects.
Fox-Fordyce disease is a chronic disorder of the apocrine glands which affects mostly young women. There are few reports in prepubescent patients, although, according to more recent literature, the disease is little diagnosed in this age group. The typical lesions are firm, skin colored or yellowish papules, restricted to areas where there are apocrine glands like armpits, pubic area, areola and, more rarely, periumbilical and pre-sternal areas.
The affected areas show reduction of sweating, although the disease might be associated with hyperidrosis, as well as rarefaction or even absence of hairs. Itch is an invariable symptom, which can be aggravated by emotional factors, heat, and during the menstrual period.
The etiology remains unknown. It is postulated that a hormonal disturbance is involved, although no laboratorial abnormality has been detected.
So far no genetic factor has been blamed either, despite the existence of familial cases. Besides, her laboratorial exams were normal and there were no clinical signs of hormonal alterations.
The physiopathology consists on the obstruction of the apocrine gland duct by a keratin plug in its insertion on the hair follicle wall, which causes secretion retention with consequent rupture of the glandular structure and secondary inflammation of the dermis. The extravasation of the glandular content can be the cause of the itch. The histopathological exam can show spongiosis and spongiotic vesiculation of the follicular infundibulum adjacent to the exit of the apocrine gland duct.
In some cases a keratin plug can be seen above this area. An associated mild inflammatory infiltrate is described, which can be composed of chronic inflammatory cells and neutrophils.
The histopathological findings of the present case were compatible with the literature, confirming the diagnosis of Fox-Fordyce Disease. On the case reported, other hypothesis were considered, like keratosis pilaris and lichen planopilaris, which were refuted by the histopathological exam. Other differential diagnoses are amyloidosis lichenoides, lichen nitidus, eruptive syringoma, contact dermatitis, infectious folliculitis and scabies.
Fox-Fordyce Disease is chronic and might have partial or complete remission after menopause, with the use of contraceptives and during pregnancy. Various treatments were suggested, including the administration of estrogens via oral contraceptives, topical, intralesional or systemic corticosteroids, topical and oral retinoid, topical clindamicin, pimecrolimus, phototherapy and surgical treatments like electro coagulation and curettage with liposuction.
On the reported case we preferred not to use oral contraceptives due to the age of the patient. The use of topical corticosteroid was deferred as it would be applied to a fold area and thin skin, which could cause atrophy and stretch marks.
Open menu Brazil. Anais Brasileiros de Dermatologia. Open menu. Abstract Resumo English Resumo Portuguese. Text EN Text English. Apocrine glands; Fox-Fordyce disease; Retinoids; Treatment outcome. Apocrine sweat retention in man. Fox-Fordyce disease apocrine miliaria. AMA Arch Dermatol. Fox-Fordyce disease: diagnosis with transverse histologic sections.
J Am Acad Dermatol. Axillary Fox-Fordyce disease treated with liposuction-assisted curettage. Arch Dermatol. Pimecrolimus is effective in Fox-Fordyce disease. Int J Dermatol. Patterns histopathologic of Fox-Fordyce disease. Am J Dermatopathol. Fox fordyce disease in a prepubertal girl. Pediatr Dermatol. Fox-Fordyce disease in daughter and father. Fox-Fordyce disease in a male patient - response to oral retinoid treatment.
Clin Exp Dermatol. Fox-Fordyce disease. Control with tretinoin cream. Fox-Fordyce disease treated with topical clindamycin solution. An Bras Dermatol. History Received 29 Mar Accepted 20 Apr Figures 2. Sociedade Brasileira de Dermatologia Av. Rio Branco, 39 Stay informed of issues for this journal through your RSS reader.
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adapaleno #differin #acne O Differin 0,3% Galderma 30gr Gel é um medicamento dermatológico apresentado em gel destinado a tratar cravos e. Buy Acne Treatment Differin Gel, 30 Day Supply, Retinoid Treatment for Face with % Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin. The 5 Best Drugstore Products From Walmart, According to Derms | Differin is an over-the-counter retinoid, aka a Vitamin A derivative that treats acne and. Tratamentos De Pele. Pomada para Tratamento de Acne com 10% de Enxofre, Potência Máxima, 73, California Gold Sadly benzoyl peroxide and my differin gel just made it worse so. More Filters. Clin Exp Dermatol. Prevalence of facial acne in adults. Incision biopsy of the right armpit showed hypekeratosis, parakeratosis and irregular acanthosis over the area of the apocrine gland exit, as well as spongiosis along the epidermis also involving the hair follicle, which still showed neutrophils exocytosis.Skip to search form Skip to main content Skip to account menu. DOI: Save to Library Save. Create Alert Alert. Share This Paper. Background Citations. Citation Type. Has PDF. More Filters. Highly Influenced. View 10 excerpts, cites background. View 7 excerpts, cites background. Motta Medicine. Ozonized oils: a review of its quality control, stability and effectiveness in the treatment of Acne vulgaris Gabriela S.
Teixeira , Stacy Ondina , A. Cruz , T. As an alternative, ozone therapy … Expand. Pinto , A. Fujita , P. Menezes , V. Bagnato Biology. Ferreira Artigo apresentado ao curso de graduacao em Fisioterapia da UniCesumar — Centro Universitario de Maringa como requisito parcial para a obtencao do titulo de bacharela em Fisioterapia, sob a … Expand.
Sayar , I. Epidemiology, causes, and prevention of skin diseases J. Grob Medicine, Biology. Anxiety and skin diseases. Garrie Sa , Garrie Ev Psychology. The British journal of dermatology. The prevalence of acne in the north of Portugal J. Amado , M. Coping with Acne vulgaris V. Niemeier , J. Kupfer , M. Demmelbauer-Ebner , U. Stangier , I. Effendy , U.
Gieler Psychology, Medicine. Acne is prevalent but use of its treatments is infrequent among adolescents from the general population T. Nijsten , S. Rombouts , J. Lambert Medicine, Psychology. Prevalence of facial acne in adults. Goulden , G. Stables , W. Cunliffe Medicine. Journal of the American Academy of Dermatology. Acne and diet. Wolf , H. Matz , E. Orion Medicine. Clinics in dermatology.
The effect of a high-protein, low glycemic-load diet versus a conventional, high glycemic-load diet on biochemical parameters associated with acne vulgaris: a randomized, investigator-masked, controlled trial. Robyn N Smith , N. Mann , A. Braue , H. Varigos Medicine. Related Papers. Abstract 17 Citations 22 References Related Papers. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy opens in a new tab , Terms of Service opens in a new tab , and Dataset License opens in a new tab.
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