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Clotrimazole and betamethasone expiration. `Expired' cream may work, or not
Lee Cantrell, an associate professor of clinical pharmacology at the University of California, San Diego, with a collection of vintage expired medications.
Sandy Huffaker for ProPublica hide caption. The box of prescription drugs had been forgotten in a back closet of a retail pharmacy for so long that some of the pills predated the moon landing. Most were 30 to 40 years past their expiration dates — possibly toxic, probably worthless. But to Lee Cantrell, who helps run the California Poison Control System, the cache was an opportunity to answer an enduring question about the actual shelf life of drugs: Could these drugs from the bell-bottom era still be potent?
Cantrell called Roy Gerona, a University of California, San Francisco researcher who specializes in analyzing chemicals. Gerona grew up in the Philippines and had seen people recover from sickness by taking expired drugs with no apparent ill effects. The age of the drugs might have been bizarre, but the question the researchers wanted to answer wasn't. Pharmacies across the country in major medical centers and in neighborhood strip malls routinely toss out tons of scarce and potentially valuable prescription drugs when they hit their expiration dates.
Gerona, a pharmacist; and Cantrell, a toxicologist, knew that the term "expiration date" was a misnomer. The dates on drug labels are simply the point up to which the Food and Drug Administration and pharmaceutical companies guarantee their effectiveness, typically at two or three years.
But the dates don't necessarily mean they're ineffective immediately after they "expire" — just that there's no incentive for drugmakers to study whether they could still be usable. ProPublica has been researching why the U. One answer, broadly, is waste — some of it buried in practices that the medical establishment and the rest of us take for granted. We've documented how hospitals often discard pricey new supplieshow nursing homes trash valuable medications after patients die or move out, and how drug companies create expensive combinations of cheap drugs.
What if the system is destroying drugs that are technically "expired" but could still be safely used? In his lab, Gerona ran tests on the decades-old drugs, including some now defunct brands such as the diet pills Obocell once pitched to doctors with a portly figurine called "Mr. Obocell" and Bamadex.
Overall, the bottles contained 14 different compounds, including antihistamines, pain relievers and stimulants. All the drugs tested were in their original sealed containers. The findings surprised both researchers: A dozen of the 14 compounds were still as potent as they were when they were manufactured, some at almost percent of their labeled concentrations.
Cantrell and Gerona knew their findings had big implications. Perhaps no area of health care has provoked as much anger in recent years as prescription drugs. The news media are rife with stories of medications priced out of reach or of shortages of crucial drugs, sometimes because producing them is no longer profitable.
Tossing such drugs when they expire is doubly hard. And that doesn't include the costs of expired drugs at long-term-care and retail pharmacies and in consumer medicine cabinets. Pharmacist Candy Tin checks dates and lot numbers with pharmacy technician Nikki Wong to pull expired medications at Newton-Wellesley Hospital. Erik Jacobs for ProPublica hide caption. After Cantrell and Gerona published their findings in Archives of Internal Medicine insome readers accused them of being irresponsible and advising patients that it was OK to take expired drugs.
Cantrell says they weren't recommending the use of expired medication, just reviewing the arbitrary way the dates are set. But after a brief burst of attention, the response to their study faded. That raises an even bigger question: If some drugs remain effective well beyond the date on their labels, why hasn't there been a push to extend their expiration dates?
It turns out that the FDA, the agency that helps set the dates, has long known the shelf life of some drugs can be extended, sometimes by years. For decades, the federal government has stockpiled massive stashes of medication, antidotes and vaccines in secure locations throughout the country.
The drugs are worth tens of billions of dollars and would provide a first line of defense in case of a large-scale emergency. Maintaining these stockpiles is expensive. The drugs have to be kept secure and at the proper humidity and temperature so they don't degrade. Luckily, the country has rarely needed to tap into many of the drugs, but this means they often reach their expiration dates. Though the government requires pharmacies to throw away expired drugs, it doesn't always follow these instructions itself.
Instead, for more than 30 years, it has pulled some medicines and tested their quality. The idea that drugs expire on specified dates goes back at least a half-century, when the FDA began requiring manufacturers to add this information to the label. The time limits allow the agency to ensure medications work safely and effectively for patients. To determine a new drug's shelf life, its maker zaps it with intense heat and soaks it with moisture to see how it degrades under stress.
It also checks how it breaks down over time. The drug company then proposes an expiration date to the FDA, which reviews the data to ensure they support the date and then approves it.
Despite the difference in drugs' makeup, most "expire" after two or three years. Once a drug is launched, the makers run tests to ensure it continues to be effective up to its labeled expiration date.
Since they are not required to check beyond it, most don't, largely because regulations make it expensive and time-consuming for manufacturers to extend expiration dates, says Yan Wu, an analytical chemist who is part of a focus group at the American Association of Pharmaceutical Scientists that looks at the long-term stability of drugs.
Most companies, she said, would rather sell new drugs and develop additional products. Pharmacists and researchers say there is no economic "win" for drug companies to investigate further. They ring up more sales when medications are tossed as "expired" by hospitals, retail pharmacies and consumers despite retaining their safety and effectiveness.
Industry officials say patient safety is their highest priority. Olivia Shopshear, director of science and regulatory advocacy for the drug industry trade group Pharmaceutical Research and Manufacturers of America, says expiration dates are chosen "based on the period of time when any given lot will maintain its identity, potency and purity, which translates into safety for the patient. That being said, it's an open secret among medical professionals that many drugs maintain their ability to combat ailments well after their labels say they don't.
One pharmacist says he sometimes takes home expired over-the-counter medicine from his pharmacy so he and his family can use it. The federal agencies that stockpile drugs — including the military, the Centers for Disease Control and Prevention and the U. Department of Veterans Affairs — have long realized the savings in revisiting expiration dates.
Inthe Air Force, hoping to save on replacement costs, asked the FDA if certain drugs' expiration dates could be extended. Each year, drugs from the stockpiles are selected based on their value and pending expiration, and analyzed in batches to determine whether their end dates could be safely extended.
For several decades, the program has found that the actual shelf life of many drugs is well beyond the original expiration dates. A study of drugs tested by the program showed that two-thirds of the expired medications were stable every time a lot was tested.
Each of them had their expiration dates extended, on average, by more than four years, according to research published in the Journal of Pharmaceutical Sciences. Some that failed to hold their potency include the common asthma inhalant albuterol, the topical rash spray diphenhydramine, and a local anesthetic made from lidocaine and epinephrine, the study said.
But neither Cantrell nor Dr. Cathleen Clancy, associate medical director of National Capital Poison Center, a nonprofit organization affiliated with the George Washington University Medical Center, had heard of anyone being harmed by any expired drugs.
Cantrell says there has been no recorded instance of such harm in medical literature. Marc Young, a pharmacist who helped run the extension program from tosays it has had a "ridiculous" return on investment.
Hussain is now president of the National Institute for Pharmaceutical Technology and Education, an organization of 17 universities working to reduce the cost of pharmaceutical development. He says the high price of drugs and shortages make it time to re-examine drug expiration dates in the commercial market. The pharmacy at Newton-Wellesley Hospital. Some medical providers have pushed for a changed approach to drug expiration dates — with no success.
Inthe American Medical Association, foretelling the current prescription drug crisis, adopted a resolution urging action. The shelf life of many drugs, it wrote, seems to be "considerably longer" than their expiration dates, leading to "unnecessary waste, higher pharmaceutical costs, and possibly reduced access to necessary drugs for some patients. Pharmacopeial Convention, which sets standards for drugs, and PhRMA asking for a re-examination of expiration dates.
I think there's considerable waste. On a recent weekday, Berkowitz sorted through bins and boxes of medication in a back hallway of the hospital's pharmacy, peering at expiration dates. As the pharmacy's assistant director, he carefully manages how the facility orders and dispenses drugs to patients. Running a pharmacy is like working in a restaurant because everything is perishable, he says, "but without the free food. David Berkowitz, assistant director of clinical pharmacy at Newton-Wellesley Hospital, says that the hospital has to throw out many drugs that are probably safe to use.
Federal and state laws prohibit pharmacists from dispensing expired drugs, and The Joint Commission, which accredits thousands of health care organizations, requires facilities to remove expired medication from their supply. So at Newton-Wellesley, outdated drugs are shunted to shelves in the back of the pharmacy and marked with a sign that says: "Do Not Dispense. And then the bins fill again. One of the plastic boxes is piled with EpiPens — devices that automatically inject epinephrine to treat severe allergic reactions.
These are from emergency kits that are rarely used, which means they often expire. Berkowitz counts them, tossing each one with a clatter into a separate container: " The devices had been donated by consumers, which meant they could have been stored in conditions that would cause them to break down, like a car's glove box or a steamy bathroom.
The EpiPens also contain liquid medicine, which tends to be less stable than solid medications. Testing showed 24 of the 40 expired devices contained at least 90 percent of their stated amount of epinephrine, enough to be considered as potent as when they were made.
All of them contained at least 80 percent of their labeled concentration of medication. The takeaway? Even EpiPens stored in less than ideal conditions may last longer than their labels say they do, and if there's no other option, an expired EpiPen may be better than nothing, Cantrell says.
At Newton-Wellesley, Berkowitz keeps a spreadsheet of every outdated drug he throws away. The pharmacy sends what it can back for credit, but it doesn't come close to replacing what the hospital paid. Then there's the added angst of tossing drugs that are in short supply.
Berkowitz picks up a box of sodium bicarbonate, which is crucial for heart surgery and to treat certain overdoses. It's being rationed because there's so little available. He holds up a purple box of atropine, which gives patients a boost when they have low heart rates. It's also in short supply. In the federal government's stockpile, the expiration dates of both drugs have been extended, but they have to be thrown away by Berkowitz and other hospital pharmacists.
- Clotrimazole and betamethasone expiration
Most were 30 to 40 years past their expiration dates — possibly toxic, probably worthless. But to Lee Cantrell, who helps run the California Poison Control System, the cache was an opportunity to answer an enduring question about the actual shelf life of drugs: Could these drugs from the bell-bottom era still be potent? Cantrell called Roy Gerona, a University of California, San Francisco researcher who specializes in analyzing chemicals.
Gerona grew up in the Philippines and had seen people recover from sickness by taking expired drugs with no apparent ill effects. The age of the drugs might have been bizarre, but the question the researchers wanted to answer wasn't. Pharmacies across the country in major medical centers and in neighborhood strip malls routinely toss out tons of scarce and potentially valuable prescription drugs when they hit their expiration dates. Gerona, a pharmacist; and Cantrell, a toxicologist, knew that the term "expiration date" was a misnomer.
The dates on drug labels are simply the point up to which the Food and Drug Administration and pharmaceutical companies guarantee their effectiveness, typically at two or three years. But the dates don't necessarily mean they're ineffective immediately after they "expire" — just that there's no incentive for drugmakers to study whether they could still be usable. ProPublica has been researching why the U.
One answer, broadly, is waste — some of it buried in practices that the medical establishment and the rest of us take for granted. We've documented how hospitals often discard pricey new supplies , how nursing homes trash valuable medications after patients die or move out, and how drug companies create expensive combinations of cheap drugs.
What if the system is destroying drugs that are technically "expired" but could still be safely used? In his lab, Gerona ran tests on the decades-old drugs, including some now defunct brands such as the diet pills Obocell once pitched to doctors with a portly figurine called "Mr. Obocell" and Bamadex. Overall, the bottles contained 14 different compounds, including antihistamines, pain relievers and stimulants.
All the drugs tested were in their original sealed containers. The findings surprised both researchers: A dozen of the 14 compounds were still as potent as they were when they were manufactured, some at almost percent of their labeled concentrations.
Cantrell and Gerona knew their findings had big implications. Perhaps no area of health care has provoked as much anger in recent years as prescription drugs. The news media are rife with stories of medications priced out of reach or of shortages of crucial drugs, sometimes because producing them is no longer profitable. Tossing such drugs when they expire is doubly hard.
And that doesn't include the costs of expired drugs at long-term-care and retail pharmacies and in consumer medicine cabinets. Pharmacist Candy Tin checks dates and lot numbers with pharmacy technician Nikki Wong to pull expired medications at Newton-Wellesley Hospital. Erik Jacobs for ProPublica hide caption. After Cantrell and Gerona published their findings in Archives of Internal Medicine in , some readers accused them of being irresponsible and advising patients that it was OK to take expired drugs.
Cantrell says they weren't recommending the use of expired medication, just reviewing the arbitrary way the dates are set. But after a brief burst of attention, the response to their study faded. That raises an even bigger question: If some drugs remain effective well beyond the date on their labels, why hasn't there been a push to extend their expiration dates? It turns out that the FDA, the agency that helps set the dates, has long known the shelf life of some drugs can be extended, sometimes by years.
For decades, the federal government has stockpiled massive stashes of medication, antidotes and vaccines in secure locations throughout the country. The drugs are worth tens of billions of dollars and would provide a first line of defense in case of a large-scale emergency.
Maintaining these stockpiles is expensive. The drugs have to be kept secure and at the proper humidity and temperature so they don't degrade. Luckily, the country has rarely needed to tap into many of the drugs, but this means they often reach their expiration dates. Though the government requires pharmacies to throw away expired drugs, it doesn't always follow these instructions itself. Instead, for more than 30 years, it has pulled some medicines and tested their quality.
The idea that drugs expire on specified dates goes back at least a half-century, when the FDA began requiring manufacturers to add this information to the label. The time limits allow the agency to ensure medications work safely and effectively for patients. To determine a new drug's shelf life, its maker zaps it with intense heat and soaks it with moisture to see how it degrades under stress.
It also checks how it breaks down over time. The drug company then proposes an expiration date to the FDA, which reviews the data to ensure they support the date and then approves it. Despite the difference in drugs' makeup, most "expire" after two or three years.
Once a drug is launched, the makers run tests to ensure it continues to be effective up to its labeled expiration date. Since they are not required to check beyond it, most don't, largely because regulations make it expensive and time-consuming for manufacturers to extend expiration dates, says Yan Wu, an analytical chemist who is part of a focus group at the American Association of Pharmaceutical Scientists that looks at the long-term stability of drugs.
Most companies, she said, would rather sell new drugs and develop additional products. Pharmacists and researchers say there is no economic "win" for drug companies to investigate further.
They ring up more sales when medications are tossed as "expired" by hospitals, retail pharmacies and consumers despite retaining their safety and effectiveness. Industry officials say patient safety is their highest priority. Olivia Shopshear, director of science and regulatory advocacy for the drug industry trade group Pharmaceutical Research and Manufacturers of America, says expiration dates are chosen "based on the period of time when any given lot will maintain its identity, potency and purity, which translates into safety for the patient.
That being said, it's an open secret among medical professionals that many drugs maintain their ability to combat ailments well after their labels say they don't. One pharmacist says he sometimes takes home expired over-the-counter medicine from his pharmacy so he and his family can use it.
The federal agencies that stockpile drugs — including the military, the Centers for Disease Control and Prevention and the U. Department of Veterans Affairs — have long realized the savings in revisiting expiration dates.
In , the Air Force, hoping to save on replacement costs, asked the FDA if certain drugs' expiration dates could be extended. Each year, drugs from the stockpiles are selected based on their value and pending expiration, and analyzed in batches to determine whether their end dates could be safely extended.
For several decades, the program has found that the actual shelf life of many drugs is well beyond the original expiration dates. A study of drugs tested by the program showed that two-thirds of the expired medications were stable every time a lot was tested. Each of them had their expiration dates extended, on average, by more than four years, according to research published in the Journal of Pharmaceutical Sciences.
Some that failed to hold their potency include the common asthma inhalant albuterol, the topical rash spray diphenhydramine, and a local anesthetic made from lidocaine and epinephrine, the study said.
But neither Cantrell nor Dr. Cathleen Clancy, associate medical director of National Capital Poison Center, a nonprofit organization affiliated with the George Washington University Medical Center, had heard of anyone being harmed by any expired drugs. Cantrell says there has been no recorded instance of such harm in medical literature. Marc Young, a pharmacist who helped run the extension program from to , says it has had a "ridiculous" return on investment. Hussain is now president of the National Institute for Pharmaceutical Technology and Education, an organization of 17 universities working to reduce the cost of pharmaceutical development.
He says the high price of drugs and shortages make it time to re-examine drug expiration dates in the commercial market. You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.
Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. This site complies with the HONcode standard for trustworthy health information: verify here.
This content does not have an English version. This content does not have an Arabic version. See more conditions. Products and services. Precautions Drug information provided by: IBM Micromedex If your skin infection does not improve within 1 week for jock itch or ringworm of the body, and 2 weeks for athlete's foot, or if it becomes worse, check with your doctor. Thank you for subscribing!
❾-50%}Clotrimazole and betamethasone expiration.That Drug Expiration Date May Be More Myth Than Fact
The pharmacy at Newton-Wellesley Hospital. Some medical providers have pushed for a changed approach to drug expiration dates — with no success. In , the American Medical Association, foretelling the current prescription drug crisis, adopted a resolution urging action. The shelf life of many drugs, it wrote, seems to be "considerably longer" than their expiration dates, leading to "unnecessary waste, higher pharmaceutical costs, and possibly reduced access to necessary drugs for some patients.
Pharmacopeial Convention, which sets standards for drugs, and PhRMA asking for a re-examination of expiration dates. I think there's considerable waste.
On a recent weekday, Berkowitz sorted through bins and boxes of medication in a back hallway of the hospital's pharmacy, peering at expiration dates. As the pharmacy's assistant director, he carefully manages how the facility orders and dispenses drugs to patients. Running a pharmacy is like working in a restaurant because everything is perishable, he says, "but without the free food.
David Berkowitz, assistant director of clinical pharmacy at Newton-Wellesley Hospital, says that the hospital has to throw out many drugs that are probably safe to use. Federal and state laws prohibit pharmacists from dispensing expired drugs, and The Joint Commission, which accredits thousands of health care organizations, requires facilities to remove expired medication from their supply.
So at Newton-Wellesley, outdated drugs are shunted to shelves in the back of the pharmacy and marked with a sign that says: "Do Not Dispense. And then the bins fill again. One of the plastic boxes is piled with EpiPens — devices that automatically inject epinephrine to treat severe allergic reactions. These are from emergency kits that are rarely used, which means they often expire.
Berkowitz counts them, tossing each one with a clatter into a separate container: " The devices had been donated by consumers, which meant they could have been stored in conditions that would cause them to break down, like a car's glove box or a steamy bathroom. The EpiPens also contain liquid medicine, which tends to be less stable than solid medications. Testing showed 24 of the 40 expired devices contained at least 90 percent of their stated amount of epinephrine, enough to be considered as potent as when they were made.
All of them contained at least 80 percent of their labeled concentration of medication. The takeaway? Even EpiPens stored in less than ideal conditions may last longer than their labels say they do, and if there's no other option, an expired EpiPen may be better than nothing, Cantrell says.
At Newton-Wellesley, Berkowitz keeps a spreadsheet of every outdated drug he throws away. The pharmacy sends what it can back for credit, but it doesn't come close to replacing what the hospital paid. Then there's the added angst of tossing drugs that are in short supply. Berkowitz picks up a box of sodium bicarbonate, which is crucial for heart surgery and to treat certain overdoses. It's being rationed because there's so little available.
He holds up a purple box of atropine, which gives patients a boost when they have low heart rates. It's also in short supply. In the federal government's stockpile, the expiration dates of both drugs have been extended, but they have to be thrown away by Berkowitz and other hospital pharmacists. The FDA study of the extension program also said it pushed back the expiration date on lots of mannitol, a diuretic, for an average of five years.
Berkowitz has to toss his out. Expired naloxone? Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.
This site complies with the HONcode standard for trustworthy health information: verify here. This content does not have an English version.
Now as I tell you this, please realize I am referring to basic, general creams that you can buy over the counter, such as hydrocortisone, triple antibiotic ointment, arthritic and muscle ache rubs, anti-itch creams and anti-fungal products. If you're only a few months past the date and the product looks normal, try it.
If you are years beyond, it's worth the few dollars to get a fresh tube. Use common sense--if your cream has a funky odor, tainted color or change in appearance, toss it.
If it is dried out or has been exposed to heat or humidity, toss it. Prescribed creams are another story. If your doctor ordered something for you years ago, and you want to reuse it, get his approval first--there are certain prescription creams that shouldn't be used beyond their expiration date. For example, the anti-cancer creams Efudex and Carac shouldn't be used beyond their expiration date.
Drug information provided by: IBM Micromedex. It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects or skin irritation. This medicine is for use on the skin only. Do not get it in your eyes, mouth, or vagina. Do not use it on skin areas that have cuts, scrapes, or burns.
If it does get on these areas, rinse it off right away with water. This medicine should come with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions. This medicine should only be used for skin conditions that your doctor is treating.
What happens if you use a topical medication after the expiration date? I've done this before and not seen or felt any adverse reaction. Probably nothing, in the case of most over-the-counter products. The expiration date on creams is really the date at which point the manufacturer is willing to guarantee that their product is at least 90 percent potent. After the date, all bets are off.
The stuff either works or it doesn't, but there is no assurance. Now as I tell you this, please realize I am referring to basic, general creams that you can buy over the counter, such as hydrocortisone, triple antibiotic ointment, arthritic and muscle ache rubs, anti-itch creams and anti-fungal products. If you're only a few months past the date and the product looks normal, try it. If you are years beyond, it's worth the few dollars to get a fresh tube.
Use common sense--if your cream has a funky odor, tainted color or change in appearance, toss it. If it is dried out or has been exposed to heat or humidity, toss it.
Prescribed creams are another story. If your doctor ordered something for you years ago, and you want to reuse it, get his approval first--there are certain prescription creams that shouldn't be used beyond their expiration date.
For example, the anti-cancer creams Efudex and Carac shouldn't be used beyond their expiration date. Neither should Aldara, which is for peri-anal and genital warts and is seeking FDA approval to treat skin cancer. It's just not worth the risk. I noticed my Stonyfield yogurt contains inulin, and yet they advertise that they are "all natural.
Their yogurt is all natural. Inulin is considered a "prebiotic," meaning it feeds the friendly bacteria present in the yogurt and your GI tract. Inulin is a non-digestible fiber. Another such fiber is fructo-oligosaccharides, or FOS. These fibers naturally occur in foods such as artichokes, asparagus, onions, garlic and chicory.
Some research supports the fact that inulin and FOS are enhancers and feed the friendly bacteria, which translates to better digestive health and less risk for constipation. The more friendly bacteria in our gut, the better. Other research regarding inulin and FOS point out its downside and say that it feeds both friendly and infectious bacteria, therefore leading to GI problems, cramping and bloating.
Perhaps the most beneficial effect of inulin, and least questioned, is its ability to increase calcium absorption and, therefore, bone-mineral density. This is great, if bone loss or osteoporosis are of concern. Inulin should not be confused with insulin, a hormone in the body. These are two completely different animals. This information is not intended to treat, cure or diagnose your condition.
Suzy Cohen is a registered pharmacist. To contact her, visit www. By Suzy Cohen, R.
Based on conforming stability data, FDA has approved a reduced expiration period of Months and future lots are being labeled accordingly. 2 Answers - Posted in: betamethasone, mupirocin, prescription - Answer: Once a drug has past its expiry date the manufacturer can no longer. Have a tube of Clotrimazole Beta. Dipro. cream, 1%. Look at the metal end of the tube and you will see the expiration date. Be sure to use the powder after clotrimazole and betamethasone combination cream has been applied and has disappeared into the skin. Get information on Clotrimazole; Betamethasone Skin Cream including uses, dosage details, Throw away any unused medicine after the expiration date. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID, plus expertise on managing health. All rights reserved. Four scientists who worked on the FDA extension program told ProPublica something like that could work for drugs stored in hospital pharmacies, where conditions are carefully controlled. Even EpiPens stored in less than ideal conditions may last longer than their labels say they do, and if there's no other option, an expired EpiPen may be better than nothing, Cantrell says. Do not use it on skin areas that have cuts, scrapes, or burns. But after a brief burst of attention, the response to their study faded. Once a drug is launched, the makers run tests to ensure it continues to be effective up to its labeled expiration date.Drug information provided by: IBM Micromedex. If your skin infection does not improve within 1 week for jock itch or ringworm of the body, and 2 weeks for athlete's foot, or if it becomes worse, check with your doctor. Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems.
The risk is greater for children and patients who use large amounts for a long time. Talk to your doctor right away if you have more than one of these symptoms while you are using this medicine: blurred vision, dizziness or fainting, a fast, irregular, or pounding heartbeat, increased thirst or urination, irritability, or unusual tiredness or weakness.
Check with your doctor right away if you have a skin rash, burning, stinging, swelling, redness, or irritation on the skin. Check with your doctor right away if blurred vision, difficulty with reading, or any other change in vision occurs during or after treatment. Your doctor may want your eyes be checked by an ophthalmologist eye doctor. To help clear up your skin infection completely and to help make sure it does not return, the following good health habits are important:.
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All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.
This site complies with the HONcode standard for trustworthy health information: verify here. This content does not have an English version.
This content does not have an Arabic version. See more conditions. Products and services. Precautions Drug information provided by: IBM Micromedex If your skin infection does not improve within 1 week for jock itch or ringworm of the body, and 2 weeks for athlete's foot, or if it becomes worse, check with your doctor.
Thank you for subscribing! Sorry something went wrong with your subscription Please, try again in a couple of minutes Retry. NEW — Man Overboard!
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