Looking for: - Isotretinoin/paracetamol | SpringerLink Click here Isotretinoin | DermNet DermNet provides Google Translate, a free machine translation service. Note that this may not provide an exact translation in all languages. Home arrow-right-small-blue Topics A—Z arrow-right-small-blue Isotretinoin. Isotretinoin cis retinoic acid is a vitamin-A derivative retinoid. The liver naturally makes small quantities of isotretinoin from vitamin-A, but the drug we prescribe is made synthetically. Isotretinoin was developed in the s, but only started being used in the mid s. Isotretinoin is a very effective medication for the treatment of acne. Originally licensed for use in severe disease, it is increasingly prescribed for all grades of acne. Isotretinoin is also useful for other follicular conditions, such as:. It has also been used as an adjuvant in neuroblastoma. Blood donation by males and females on isotretinoin is not allowed in case the blood is used for a pregnant wo